Personally, I have an old notebook (Dell E6430) that sits around doing very little, so I run both TabloRipper and MCEBuddy on that PC.
I've scheduled TabloRipper to run "after" all my shows are done for the day, so it kicks off around 10 PM. MCEBuddy monitors the TabloRipper output folder and wakes up as each show is ripped. Both are done before I wake up and might want to use the notebook for "something else".
TabloRipper takes less than 5 minutes per 1 hour show to "rip". Then MCEBuddy takes about 1 hour per 1 hour show to strip commercials. Like I said, an old notebook. But plenty fast enough for me.
There are plenty of people running this combo on newer systems with much quicker processing times (I expect they'll chime in if you ask). But even a slow PC gets the job done.
PS: I run Plex on a Synology DS713+ with great results. And yes, this combo works fine, but have no experience with the new "cloud" offering. I have TabloRipper save on the PC, then MCEBuddy saves to the NAS.