Note 1: Defraggler can defrag NTFS and FAT hard drives, as well as exFAT format USB drives. We do not recommend that you defrag USB drives that have not been formatted as exFAT. Generally, they will not benefit by being defragmented and theoretically defragging can shorten their lifespan.
Tablo does not use any of those “hard drives” or more specifically - filesystens. Not being an MS Windows proprietary filesystem, an ext4 journaling filesystem doesn’t have the same fragmenting characteristics as NTFS.